Iran has initiated a large-scale missile attack targeting Israeli locations as a reaction to ongoing airstrikes that have devastated parts of Tehran and several Iranian cities, reportedly resulting in over 70 fatalities, including key military leaders and nuclear experts.

The Iranian news agency announced the commencement of an 'overwhelming Iranian response' with the launch of hundreds of ballistic missiles aimed at Israel, prompting the Israeli home front command to instruct citizens to seek shelter after detecting missile launches from Iranian territory.

Air raid sirens were activated in major cities, including Tel Aviv and Jerusalem, with live footage showing plumes of smoke rising from hit areas in Tel Aviv, and reports indicated the outbreak of fires near the Ministry of Defense.

Emergency services confirmed that nine of the missiles struck central Israel, injuring approximately 40 individuals, while Israeli authorities described the extent of the damage in the greater Tel Aviv area as unprecedented, with numerous buildings and vehicles severely damaged.

The police chief for the Tel Aviv district reported significant destruction, stating that several buildings had collapsed, and rescue operations were underway to reach individuals trapped in sealed shelters.

A spokesperson for the Israel Defense Forces (IDF) urged the public to refrain from sharing images of the destruction, describing such actions as assistance to the enemy during active conflict and a compromise to national security.

An Israeli official disclosed that U.S. forces are engaged in countering the Iranian threat against Israel.

On the Iranian side, the Revolutionary Guard confirmed attacks on dozens of Israeli targets, claiming they utilized 'smart systems with high precision' in an operation dubbed 'Promised Response 3'.

An Iranian official was quoted asserting that 'no safe place will exist in Israel' and vowed that Israel would pay a heavy price for the deaths of Iranian leaders and citizens.

Iranian media reported the unprecedented launch of missiles from military submarines toward Israel.

In a retaliatory stance, Israeli officials indicated plans to target civilian areas in response to Iran's missile barrage.

Israeli Defense Minister Yoav Gallant stated that Iran overstepped 'red lines' by firing missiles at civilian zones, warning of severe repercussions for its actions.

A Revolutionary Guard spokesperson cautioned Israel against targeting economic centers and energy infrastructure, asserting that any strategic misstep could result in attacks on such facilities.

The Israeli military characterized its operations against Iran as at a peak, with actions extended beyond nuclear sites to include ballistic missile targets.

The IDF reported that its airstrikes have inflicted substantial damage on Iranian nuclear facilities, while an Israeli military official affirmatively stated that Israeli forces maintain control over Iranian airspace.

Iran's military announced the downing of two Israeli fighter jets and claims to have shot down an Israeli drone in Qom province.

Concurrently, the IDF alleged that Iran had launched roughly 100 drones in retaliation for the strikes against it, with reports of intercepted drones near southern Syria and off the Lebanese coast, in addition to the Iron Dome intercepting three drones over the Red Sea.

The new commander of the Iranian Revolutionary Guard, Ahmad Vahidi, threatened that Iran would soon unleash severe retaliatory strikes against Israel.

Following the Iranian missile strikes, Ben Gurion Airport in Tel Aviv was shut down indefinitely, and Israel's air defense units were placed on high alert for potential Iranian responses.

Hospitals across Israel were also reported to be in a heightened state of readiness, with patients being relocated to underground facilities.

Iranian news agencies stated that the ongoing Israeli assaults have resulted in at least 78 fatalities and 329 injuries in residential zones within Tehran province alone.

Additional reports indicated 18 fatalities and 35 injuries in the East Azerbaijan province, with several fatalities reported in attacks targeting the city of Tabriz.

Israeli airstrikes have been reported to target locations including the primary Natanz uranium enrichment facility.

The Israeli military confirmed that dozens of fighter jets participated in what it called the 'initial strike' deep within Iran, following up with subsequent attacks that reportedly involved 200 jets targeting around 100 sites across Iran.

The IDF maintains that its ongoing operations specifically focus on missile systems utilized by the Iranian regime, and sources within the Israeli military indicated that operational successes have involved extensive planning and intelligence regarding key Iranian military leaders and scientists.

Israeli officials remarked that these strikes were executed with detailed knowledge of their targets to achieve maximum impact.

The Iranian Supreme Leader, Ali Khamenei, acknowledged the deaths of several military leaders and scholars in the Israeli offensive, underscoring that the Israeli state should expect serious retribution.

Among the deceased are reported leaders of the Iranian Revolutionary Guard and nuclear scientists.

In the meantime, Israeli Prime Minister Benjamin Netanyahu is expected to convene security consultations with top military and security officials.

Reports note that Netanyahu plans to engage in discussions with various world leaders, including U.S. President Donald Trump and Russian President Vladimir Putin, with Trump expressing strong support for Israel in its military actions against Iran.

Sources have indicated that the U.S. was aware of Israel's planned strikes against Iran ahead of time and provided intelligence support.

While specifics have not been disclosed, it has been noted that the U.S. is prepared to assist in Israel's defense if warranted.